Adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

We have demonstrated that molecular-level simulations can inform subcellular models of synaptic plasticity. Several computational tools, from molecular dynamics and Brownian dynamics simulations to bioinformatics approaches, were combined to constrain a kinetic model of the adenylyl cyclase type 5 (AC5)-dependent signaling system in the striatum. A better understanding of this system is crucial when predicting which neuromodulatory signaling events will lead to learning in the synapses, such as during reward learning in this system. The publication by Bruce et al (2019)was highlighted by the press, see https://www.alphagalileo.org/Item-Display/ItemId/185865

Publication: Bruce NJ, Narzi D, Trpevski D, van Keulen SC, Nair AG, Röthlisberger U, Wade RC, Carloni P, Hellgren Kotaleski J (2019) Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals, PLoS Comput Biol. 15(10):e1007382