The ultimate goal of EGI-InSPIRE is to provide European scientists and their international partners with a sustainable, reliable e-Infrastructure that can support their needs for large-scale data analysis. This is essential in order to solve the big questions facing science today, and in the decades to come. EGI-InSPIRE will coordinate the transition from a project-based system (the EGEE series) to a sustainable pan-European e-Infrastructure. The four-year project will support grids of high-performance computing (HPC) and high-throughput computing (HTC) resources. The project is ideally placed to join together the new Distributed Computing Infrastructures (DCIs) such as high throughput and high performance computing clusters, clouds and desktop grids, for the benefit of user communities within the European Research Area. EGI-InSPIRE will collect user requirements and provide support for the current and potential new user communities, for example the ESFRI projects. The project will also support the current heavy users of the infrastructure, such as high energy physics, computational chemistry and life sciences, as they move their critical services and tools from a centralised support model to one driven by their own individual communities.