SeRC scientists publishes in Lancet on prostate cancer screening

Tue, 2015-11-10 21:19 SeRC scientists at Karolinska Institutet shows that a new test for prostate cancer is better at detecting aggressive cancer than PSA. The new test, which has undergone trial in 58,818 men, discovers aggressive cancer earlier and reduces the number of false positive tests and unnecessary biopsies. The results are published in the scientific journal The Lancet Oncology.

Prostate cancer is the second most common cancer among men worldwide, with over 1.2 million diagnosed in 2012. In number of men diagnosed with prostate cancer increases and within 20 years over 2 million men are estimated to be diagnosed yearly. Currently, PSA is used to diagnose prostate cancer, but the procedure has long been controversial as it can’t distinguish between aggressive and benign cancer.

 

The new so-called STHLM3 test is a blood test that analyzes a combination of six protein markers, over 200 genetic markers and clinical data (age, family history and previous prostate biopsies). The test has been developed by researchers at Karolinska Institutet in collaboration with Thermo Fisher Scientific, which provided the protein and genetic marker assays used in the clinical study.

 

 

 
Publication:Prostate cancer screening in men 50-69 years (STHLM3): a prospective population-based diagnostic study ’, Henrik Grönberg, Jan Adolfsson, Markus Aly, Tobias Nordström, Peter Wiklund, Yvonne Brandberg, James Thompson, Fredrik Wiklund, Johan Lindberg, Mark Clements, Lars Egevad & Martin Eklund, The Lancet Oncology , online November 9, 2015 , http://dx.doi.org/10.1016/S1470-2045(15)00361-7.